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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are typically described as a focus on the practical aspects of study design that include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used different investigators and participants from different geographical regions. This type of heterogeneity, which is vital for pragmatic trials to be reliable and to reduce bias in the results is also essential. However too much heterogeneity could lead to issues with the design of the trial.

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The goal of pragmatic trials is to mimic real-life scenarios and gain maximum validity externally. They are typically commissioned by practitioners and policy makers to inform their decision making. They can also be a great method to determine the cause-effect relationship between an intervention and its outcomes. They should, however, not, be used to replace the need for explanation studies.

The pragmatism idea is controversial, and 프라그마틱 무료슬롯 무료체험 슬롯버프 (peatix.com) there are questions about whether pragmatic trials can replace tests for explanations or if they should serve as an addition to them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform the practice and policy decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a practical study, including recruitment, design, delivery of the intervention and follow-up.

The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This is a sign that the health sciences community is becoming more acquaint to the subject of pragmatic thinking. It is important to remember that the majority of studies were conducted in primary-care settings.